Inadequate incentive and opportunity to replicate the results of small-scale research projects have contributed to a crisis of confidence in the reproducibility and transparency of many studies in the social and biomedical science literature [1, 2]. Strategies to combat this crisis include project registration, support for replication studies, declaration of conflicts of interest, sharing of data sets and full reporting of methodologies [2, 3]. A recent publication from our group, on the effects of adaptation to a ketogenic low carbohydrate, high fat (LCHF) diet on metabolism and performance in world-class endurance athletes [4], attracted keen interest from both social media and scientific circles. Given the high level of publicity around the project, we determined to undertake a replication study to test the robustness of our earlier findings, to address some of the challenges/criticism it received, and to extend both the scientific knowledge and practical implementation around its underpinning theme.
These were free living subjects who were not provided with any other foods apart from either eggs or eggs substitute to consume as part of a low carbohydrate diet. No restrictions were given towards energy intake. Subjects received individual and personalized dietary counseling from Registered Dietitians prior to the dietary intervention. Detailed dietary booklets, specific to each dietary treatment, were provided outlining dietary goals, lists of appropriate foods, recipes, sample meal plans, and food record log sheets. Subjects received weekly follow-up counseling during which body mass was measured, compliance was assessed, and further dietetic education was provided. A three-day weighed food records was obtained at baseline to assess habitual nutrient intake, and a five-day records were completed during weeks 1, 6, and 12 of the intervention.
Art And Science Of Low Carbohydrate Living Epub File
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County level prevalence of Lyme and TBRF group bacteria. Supplemental file of County level Lyme and TBRF group bacteria prevalence data from citizen science collected I. scapularis ticks in the Northeastern US. 2ff7e9595c
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